Table 2: Factors predicting worse outcome of patients with GBCA (univariate and multivariate survival analyses).

CharacteristicsUnivariateMultivariate
valueHR (95% CI) value

Age (years old), ≥64 versus <64 0.920Not applicable
Sex, man versus woman 0.0671.582 (0.706–2.257) 0.187
Histological grade, 2/3 versus 1 0.001*2.074 (1.196–3.596) 0.009*
Tumor size (cm), ≥2.5 versus <2.5 0.500Not applicable
Pathological T stage, pT3/4 versus pT1/2<0.001*2.277 (1.279–4.054) 0.005*
Nodal metastasis, present versus absent 0.034*0.740 (0.333–1.643) 0.460
Distant metastasis, present versus absent 0.028*1.353 (0.732–2.500) 0.335
TNM stage, III/IV versus I/II<0.001*1.693 (0.912–3.140) 0.095
Local recurrence, present versus absent<0.001*4.595 (2.541–8.309)<0.001*
Lymphatic invasion, present versus absent<0.001*1.063 (0.524–2.159) 0.866
Vascular invasion, present versus absent 0.005*1.092 (0.620–1.924) 0.760
Perineural invasion, present versus absent 0.002*1.162 (0.601–2.249) 0.655
Resection margin involvement, present versus absent<0.013*2.060 (1.026–4.133) 0.042*
MRP2 expression, positive versus negative 0.011*1.473 (0.877–2.476) 0.143

Statistically significant.