About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 531640, 6 pages
http://dx.doi.org/10.1155/2013/531640
Research Article

Carbohydrate 19.9 Antigen Serum Levels in Liver Disease

1Department of Medical and Pediatric Sciences, Hepatology Unit, University of Catania, 95123 Catania, Italy
2International Ph.D. Program in Neuropharmacology, University of Catania, 95123 Catania, Italy
3Research Center “The Great Senescence”, University of Catania, 95125 Catania, Italy
4Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy

Received 23 June 2013; Revised 10 September 2013; Accepted 12 September 2013

Academic Editor: Aleksandra Nikolic

Copyright © 2013 Gaetano Bertino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Carbohydrate 19.9 antigen (CA19.9) has been used in the diagnosis and followup of gastrointestinal tumours. The aim of this prospective longitudinal study was the evaluation of CA19.9 levels in patients with chronic hepatitis and hepatic cirrhosis hepatitis C virus and B virus correlated. Materials and Methods. 180 patients were enrolled, 116 with HCV-related chronic liver disease (48% chronic hepatitis, 52% cirrhosis) and 64 with HBV-related chronic liver disease (86% chronic hepatitis, 14% cirrhosis). Patients with high levels of CA19.9 underwent abdominal ecography, gastroendoscopy, colonoscopy, and abdominal CT scan. Results. 51.7% of patients with HCV-related chronic liver disease and 48.4% of those with HBV-related chronic liver disease presented high levels of CA19.9. None was affected by pancreatic or intestinal neoplasia, cholestatic jaundice, or other diseases potentially able to induce Ca19.9 elevations. CA19.9 levels were elevated in 43.3% of HCV chronic hepatitis, in 56.3% of HCV cirrhosis, in 45.1% of HBV chronic hepatitis, and in 58% of HBV cirrhosis. Conclusions. CA19.9 commonly increases in the serum of patients with chronic viral hepatitis. Elevation of CA 19.9 is not specific for neoplastic disease and is related to the severity of fibrosis and to the viral aetiology of hepatitis.