Candidate Genes for Proliferative Diabetic Retinopathy

Table 3

The reported studies of polymorphisms of genes of oxidative stress and proliferative diabetic retinopathy in subjects with type 2 diabetes.

Population	Subjects with type 2 diabetes (n)	Polymorphism (rs)	Risk genotype/allele	OR (P value)^1	Reference
Caucasian-Brazilians	501 (PDR versus NDR versus dm without DR)	UCP2^2: −866G/A^3; Ala55Val^4; 45 bp Ins/Del^5	Haplotype A Val Ins	2.12 (0.006)	[53]
Slovene population (Caucasians)	577 (PDR versus dm without PDR)	eNOS 4a/4b; eNOS^6 894G>T^3 eNOS^6	aa; none	2.9 (=0.005); no association	[19]
Chinese population	8111 (PDR versus NDR versus dm without DR)	eNOS^6 4a/4b; eNOS 894G>T^7 eNOS; T −786C eNOS^8	No association (4a/b; 894G>T); 786C—antirisk	No association (4a/b; 894G>T); 786C—antirisk	[54]
Caucasian-Brazilians	630 (PDR versus NDR versus dm without DR)	eNOS^2 4a/4b; eNOS^2 894G>T^3 eNOS^2; T −786C eNOS^3	No association	No association	[55]

 ¹Odds ratio and P value in logistic regression analysis; ²uncoupling protein 2; ³866G/A (rs659366); ⁴Ala55Val (rs660339); ⁵insertion/deletion (Ins/Del) polymorphism; ⁶endothelial nitric oxide synthase; ⁷894G>T (Glu298Asp).