Candidate Genes for Proliferative Diabetic Retinopathy

Table 7

The reported studies of polyol pathway (aldose reductase/sorbitol dehydrogenase) genes and proliferative diabetic retinopathy in subjects with type 2 diabetes.

Population	Subjects with type 2 diabetes (n)	Polymorphism (rs)	Risk genotype/allele	OR (P value)^1	Reference
Japanese population	61 (PDR versus nonPDR)	AR^2 (AC)𝑛	z-4		[65]
Brazilian population	579 (PDR versus non-PDR)	−106C>T AR^2	CC	2.04 (𝑃=0.007)	[66]
Poland (Caucasians)	215 (PDR versus non-PDR versus dm without DR)	−SDH^3 C −1214G (rs2055858) and G −888C (rs3759890)	None	—	[67]

 ¹Odds ratio and P value in logistic regression analysis; ²aldose reductase; ³sorbitol dehydrogenase.