Review Article
Candidate Genes for Proliferative Diabetic Retinopathy
Table 8
The reported studies of the renin-angiotensin system and proliferative diabetic retinopathy in subjects with type 2 diabetes.
| | Population | Subjects with type 2 diabetes (n) | Polymorphism (rs) | Risk genotype/allele | OR (P value)1 | Reference |
| | Danish population (Caucasians) | 222 (PDR versus dm without DR) | ACE I/D2 | DD—no association | 1.2 (0.4) | [68] | | Slovene population (Caucasians) | 204 (PDR versus NDR versus dm without DR) | ACE I/D2 | DD—no association | 1.2 (0.4) | [69] | | Chinese population | 4385 (PDR versus NDR versus dm without DR) | ACE I/D2 | DD—no association | NA | [70] | | Chinese population | 2224 (PDR versus dm without DR) | ACE I/D2 | DD | 2.2 (<0.01) | [71] |
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1Odds ratio and P value in logistic regression analysis; 2insertion/deletion polymorphism of the angiotensin I-converting enzyme gene.
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