Research Article
Validation Thin Layer Chromatography for the Determination of Acetaminophen in Tablets and Comparison with a Pharmacopeial Method
Table 1
The factors and their levels investigated in robustness test.
| | Symbol |
Factors | Method condition | Levels | | + | − |
| | Sorbent type
(Merck, #) | Al sheet
(1.05554) | Al sheet
(1.05554) | Al sheet
(1.05570) | | Chamber type | Twin trough,
20 cm × 20 cm | Twin trough,
20 cm × 20 cm | Twin trough,
20 cm × 10 cm | | Temperature of plate activation (°C) | 120 | 130 | 110 | | Extraction time (min) | 5 | 6 | 4 | | Distance of development (cm) | 7.5 | 8.0 | 7.0 | | Wavelength (nm) | 248 | 250 | 246 | | Analyst | A | A | B |
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