Validation Thin Layer Chromatography for the Determination of Acetaminophen in Tablets and Comparison with a Pharmacopeial Method

Table 2

Experimental design matrix (2³) for robustness test.

Experiment no.	𝑋1	𝑋2	𝑋3	𝑋4	𝑋5	𝑋6	𝑋7	Acetaminophen content (𝑦𝑖) [mg · tablet^−1] in tablets^a
								P1	P2	P3
1	+	+	+	+	+	+	+	499.0	494.5	501.2
2	+	+	−	+	−	−	−	454.2	451.6	459.8
3	+	−	+	−	−	+	−	496.4	494.1	496.7
4	+	−	−	−	+	−	+	485.1	481.4	488.2
5	−	+	+	−	+	−	−	501.1	501.3	503.4
6	−	+	−	−	−	+	+	495.8	491.5	492.5
7	−	−	+	+	−	−	+	478.0	477.9	485.6
8	−	−	−	+	+	+	−	485.9	477.2	483.5
Effect of the drug
P1	−6.525	1.175	13.375	−15.325	11.675	14.675	5.075
P2	−6.579	2.078	16.521	−16.777	9.804	11.297	5.278
P3	−4.775	0.725	15.725	−12.675	10.425	9.225	6.025

aProduct 1 (P1), Product 2 (P2), Product 3 (P3).