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BioMed Research International
Volume 2013 (2013), Article ID 546354, 7 pages
http://dx.doi.org/10.1155/2013/546354
Research Article

Prevalence and Genetic Variability in Capsid L1 Gene of Rare Human Papillomaviruses (HPV) Found in Cervical Lesions of Women from North-East Brazil

1Department of Genetics, Federal University of Pernambuco, Brazil
2Gynaecological Unit, University Hospital Oswaldo Cruz, Brazil
3Gynaecological Unit, Integrated Medicine Center, Brazil
4Department of Histology and Embryology, Federal University of Pernambuco, Brazil
5Molecular Biology Laboratory, Pediatric Oncohematology Center, University of Pernambuco, Brazil
6Cidade Universitária, 50670-901, Recife, PE, Brazil

Received 20 February 2013; Revised 30 April 2013; Accepted 9 May 2013

Academic Editor: Franco Roperto

Copyright © 2013 Ana Pavla Almeida Diniz Gurgel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. A. C. De Freitas, “Vaccine strategies against human papillomavirus: a discussion focused on developing countries,” Journal of Clinical & Cellular Immunology, vol. 1, no. S4, 2012.
  3. H. Zur Hausen, “Papillomavirus infections—a major cause of human cancers,” Biochimica et Biophysica Acta, vol. 1288, no. 2, pp. F55–F78, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. A. C. De Freitas, A. P. A. D. Gurgel, B. S. Chagas, E. C. Coimbra, and C. M. M. Do Amaral, “Susceptibility to cervical cancer: an overview,” Gynecologic Oncology, vol. 126, no. 2, pp. 304–311, 2012.
  5. H. U. Bernard, R. D. Burk, Z. Chen, K. van Doorslaer, H. Z. Hausen, and E. M. de Villiers, “Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments,” Virology, vol. 401, no. 1, pp. 70–79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. E. M. De Villiers, C. Fauquet, T. R. Broker, H. U. Bernard, and H. Zur Hausen, “Classification of papillomaviruses,” Virology, vol. 324, no. 1, pp. 17–27, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Zur Hausen, “Papillomaviruses and cancer: from basic studies to clinical application,” Nature Review Cancer, vol. 2, no. 5, pp. 342–350, 2002.
  8. M. Schiffman, G. Clifford, and F. M. Buonaguro, “Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline,” Infectious Agents and Cancer, vol. 4, no. 1, article 8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. de Sanjose, W. G. V. Quint, L. Alemany et al., “Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study,” The Lancet Oncology, vol. 11, no. 11, pp. 1048–1056, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. F. P. T. Baldez Da Silva, B. S. Chagas, V. Guimarães et al., “HPV31 and HPV33 incidence in cervical samples from women in Recife, Brazil,” Genetics and Molecular Research, vol. 8, no. 4, pp. 1437–1443, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. B. S. Chagas, M. V. A. Batista, V. Guimarães, V. Q. Balbino, S. Crovella, and A. C. Freitas, “New variants of E6 and E7 oncogenes of human papillomavirus type 31 identified in Northeastern Brazil,” Gynecologic Oncology, vol. 123, no. 2, pp. 284–288, 2011.
  12. M. R. Pillai, R. Hariharan, J. M. Babu et al., “Molecular variants of HPV-16 associated with cervical cancer in Indian population,” International Journal of Cancer, vol. 125, no. 1, pp. 91–103, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. T. R. Alencar, D. M. Cerqueira, M. R. D. Cruz, P. S. Wyant, E. D. Ramalho, and C. R. F. Martins, “New HPV-16 European and non-European variants in Central Brazil,” Virus Genes, vol. 35, no. 1, pp. 1–4, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. D. M. Cerqueira, T. Raiol, N. M. C. Véras et al., “New variants of human papillomavirus type 18 identified in central Brazil,” Virus Genes, vol. 37, no. 2, pp. 282–287, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Raiol, P. S. Wyant, R. M. S. De Amorim et al., “Genetic variability and phylogeny of the high-risk HPV-31, -33, -35, -52, and -58 in Central Brazil,” Journal of Medical Virology, vol. 81, no. 4, pp. 685–692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. M. Castro, I. P. Farias, C. M. Borborema-Santos, G. Correia, and S. Astolfi-Filho, “Prevalence of human papillomavirus (HPV) type 16 variants and rare HPV types in the central Amazon region.,” Genetics and Molecular Research, vol. 10, no. 1, pp. 186–196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Pande, N. Jain, B. K. Prusty et al., “Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in North India,” Journal of Clinical Microbiology, vol. 46, no. 3, pp. 1060–1066, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. I. E. Calleja-Macias, L. L. Villa, J. C. Prado et al., “Worldwide genomic diversity of the high-risk human papillomavirus types 31, 35, 52, and 58, four close relatives of human papillomavirus type 16,” Journal of Virology, vol. 79, no. 21, pp. 13630–13640, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. I. E. Calleja-Macias, M. Kalantari, J. Huh et al., “Genomic diversity of human papillomavirus-16, 18, 31, and 35 isolates in a Mexican population and relationship to European, African, and Native American variants,” Virology, vol. 319, no. 2, pp. 315–323, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Cornut, S. Gagnon, C. Hankins et al., “Polymorphism of the capsid L1 gene of human papillomavirus types 31, 33, and 35,” Journal of Medical Virology, vol. 82, no. 7, pp. 1168–1178, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Arias-Pulido, C. L. Peyton, N. Torrez-Martínez, D. N. Anderson, and C. M. Wheeler, “Human papillomavirus type 18 variant lineages in United States populations characterized by sequence analysis of LCR-E6, E2, and L1regions,” Virology, vol. 338, no. 1, pp. 22–34, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. J. C. Prado, I. E. Calleja-Macias, H. U. Bernard et al., “Worldwide genomic diversity of the human papillomaviruses-53, 56, and 66, a group of high-risk HPVs unrelated to HPV-16 and HPV-18,” Virology, vol. 340, no. 1, pp. 95–104, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. V. Cento, N. Rahmatalla, M. Ciccozzi, A. Lo Presti, C. F. Perno, and M. Ciotti, “Human Papillomaviruses 53 and 66: clinical aspects and genetic analysis,” Virus Research, vol. 163, no. 1, pp. 212–222, 2012.
  24. F. Karlsen, M. Kalantari, A. Jenkins et al., “Use of multiple PCR primer sets for optimal detection of human papillomavirus,” Journal of Clinical Microbiology, vol. 34, no. 9, pp. 2095–2100, 1996. View at Scopus
  25. R. Staden, “The staden sequence analysis package,” Applied Biochemistry and Biotechnology B, vol. 5, no. 3, pp. 233–241, 1996. View at Scopus
  26. K. Tamura, D. Peterson, N. Peterson, G. Stecher, M. Nei, and S. Kumar, “MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods,” Molecular Biologica Land Evolution, vol. 28, no. 10, pp. 2731–2739, 2011. View at Publisher · View at Google Scholar
  27. S. Saha and G. P. S. Raghava, “BcePred: prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties,” in Proceedings of the 3rd International Conference on Artificial Immune Systems (ICARIS '04), G. Nicosia, V. Cutello, P. J. Bentley, and J. Timis, Eds., vol. 3239 of LNCS, pp. 197–204, Springer, 2004.
  28. H. Singh and G. P. S. Raghava, “ProPred1: prediction of promiscuous MHC Class-I binding sites,” Bioinformatics, vol. 19, no. 8, pp. 1009–1014, 2003.
  29. H. Singh and G. P. Raghava, “ProPred: prediction of HLA-DR binding sites,” Bioinformatics, vol. 17, no. 12, pp. 1236–1237, 2001.
  30. D. Geraets, L. Alemany, N. Guimera et al., “Detection of rare and possibly carcinogenic Human Papillomavirus genotypes as single infections in invasive cervical cancer,” The Journal of Pathology, vol. 228, no. 4, pp. 534–543, 2012. View at Publisher · View at Google Scholar
  31. L. Fu, K. van Doorslaer, Z. Chen et al., “Degradation of p53 by human Alphapapillomavirus E6 proteins shows a stronger correlation with phylogeny than oncogenicity,” PLoS ONE, vol. 5, no. 9, Article ID e12816, pp. 1–8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Mesplède, D. Gagnon, F. Bergeron-Labrecque et al., “p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes,” Journal of Virology, vol. 86, no. 1, pp. 94–107, 2012.