Prevalence and Genetic Variability in Capsid L1 Gene of Rare Human Papillomaviruses (HPV) Found in Cervical Lesions of Women from North-East Brazil

Table 3

Nucleotide sequence variation in the L1 gene of HPV-53 and HPV-54. The vertical numbers indicate the position of the nucleotide variations. HG: Histopathological grade. (*) Substitutions not previously reported.

(a)  

HPV-53 L1 gene variability	6; 6; 8; 6	6; 7; 0; 6	6; 7; 4; 4	6; 9; 1; 3	6; 9; 4; 7	7; 0; 0; 3	HG
Prototype (NC_001593.1)	C	C	A	G	C	G	CIN III
6 SE	T	T	G	A	T	A
Protein						P430S
Hydropathic index						Hydrophobic/Hydrophilic
Biological functions altered						MHC Class-I/B-cell

(b)  

HPV-54 L1 gene variability	6; 5; 5; 2	6; 5; 7; 9	6; 6; 2; 2	6; 6; 2; 4	6; 6; 2; 5	6; 9; 7; 5	HG
Prototype (NC_001676.1)	A	G	A	A	T	C	CIN I
233 PE	T	A	T*	T	C*	T
Protein	Q313H		T337S	T337S
Hydropathic index	Hydrophilic/Hydrophilic		Hydrophilic	Hydrophilic
Biological functions altered	MHC Class-I/MHC Class-II/B-cell		MHC Class-I/MHC Class-II/B-cell	MHC Class-I/MHC Class-II/B-cell