Prevalence and Genetic Variability in Capsid L1 Gene of Rare Human Papillomaviruses (HPV) Found in Cervical Lesions of Women from North-East Brazil

Table 6

Nucleotide sequence variation in the L1 gene of HPV-56, HPV-70, and HPV-81. The vertical numbers indicate the position of the nucleotide variations. HG: Histopathological grade. (*) Substitutions not previously reported. (.) Similar to the prototype sequence.

(a)  

HPV-81 L1 gene variability	7; 1; 4; 8	7; 2; 4; 9	HG
Prototype (AJ620209.1)	A	T	CIN I
106 PE	G*	A*

(b)  

HPV-56 L1 gene variability	6; 6; 6; 6	6; 9; 8; 7	HG
Prototype (X74483.1)	A	A	CIN I
35 SE	G	G

(c)  

HPV-70 L1 gene variability	6; 6; 3; 3	6; 7; 4; 1	6; 8; 0; 1	6; 8; 7; 3	6; 8; 8; 6	HG
Prototype (HPU21941)	G	T	A	A	A
41 PE	A	·	·	·	·	CIN I
42 PE	A	A	C*	G*	G*	Adenocarcinoma
Protein					T433A
Hydropathic index					Hydrophilic/Hydrophobic
Biological functions altered					MHC Class-I; B-cell