Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [¹²⁴I]-Morpholino-IPQA

Figure 3

In vitro uptake and washout phases of morpholino-[¹³¹I]IPQA in L858R (a), E746-A750 del (b), wild-type EGFR-transfected (c), and EGFR-vector (d). Liner fits of radioactivity accumulation time points show the washout rate at short duration (20–80 minutes, blue dot line) and long duration (60–120 minutes, red dot line) after initial accumulation (from (e) to (g)). Coefficient 𝐵 (slope) of the exponential washout =𝐴×exp^{(−𝐵𝑋)}. Panels (a)–(d) are shown in full scale, and panels (e)–(g) are from the same data in panels (a)–(c) but are shown in smaller scale to visualize differences in washout results.

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(d)

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(g)