Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [¹²⁴I]-Morpholino-IPQA

Table 2

Biodistribution of accumulated radioactivity (%ID/g) in different tissues at the designed time points after administration of morpholino-[¹³¹I]IPQA.

Tissue	Radioactivity (%injection dose/tissue g)
	1 hr	4 hr	24 hr	4 hr
Blood	0.124±0.000	0.076±0.000	0.030±0.000	0.009±0.000
Lung	1.319±0.001	0.776±0.001	0.239±0.000	0.119±0.000
Heart	0.240±0.002	0.191±0.001	0.076±0.000	0.676±0.001
Stomach	1.330±0.001	1.302±0.002	1.407±0.012	0.299±0.000
Liver	1.241±0.002	0.500±0.000	0.424±0.000	1.063±0.001
Spleen	0.560±0.009	0.303±0.000	0.225±0.001	0.486±0.001
Pancreas	5.443±0.002	5.334±0.002	3.232±0.004	0.389±0.002
Small intestine	0.858±0.001	0.774±0.004	0.135±0.000	0.044±0.000
Large intestine	0.807±0.002	0.289±0.000	0.301±0.000	0.021±0.000
Kidney	4.785±0.001	3.772±0.008	1.431±0.001	0.523±0.000
Bone	0.190±0.002	0.109±0.000	0.062±0.000	0.04±0.000
Muscle	0.034±0.000	0.025±0.000	0.009±0.000	0.009±0.000
Brain	0.010±0.000	0.008±0.000	0.003±0.000	0.002±0.000
L858R	0.280±0.000	0.251±0.001	0.125±0.000	0.037±0.000
E746-A750 del	0.304±0.000	0.195±0.000	0.100±0.000	0.052±0.000
EGFR	0.347±0.000	0.208±0.000	0.047±0.000	0.036±0.000
Vector	0.222±0.000	0.143±0.000	0.085±0.001	0.123±0.002

Data shown as average ± standard deviation (𝑛=3 per tumor pair).