Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [¹²⁴I]-Morpholino-IPQA

Table 3

Tumor-to-blood ratio in different tumor cells in in vitro study.

	1 hr	4 hr	24 hr	48 hr
L858R/blood	2.25±0.001	3.75±0.001	2.64±0.000	3.98±0.000^∗
E746-A750 del/blood	2.45±0.000	2.96±0.001	2.68±0.000	5.55±0.002^∗
Wild-type EGFR/blood	2.79±0.001^∗	2.91±0.000	1.22±0.000	3.87±0.001^∗
Vector/blood	1.79±0.001	1.97±0.000	2.37±0.001	13.12±0.000

Data shown as average ± standard deviation (𝑛=3 for each tumor pair). All other three cell lines were compared to L858R tumor cells at the same time point, and statistically significant difference (*𝑃<0.05) is indicated by an asterisk.