Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [¹²⁴I]-Morpholino-IPQA

Table 5

Tumor-to-vector ratio in different tumor cells in in vitro study of morpholino-[¹³¹I]IPQA and in vivo study of morpholino-[¹²⁴I]IPQA.

	PET		Biodistribution
	Baseline	Iressa	Baseline
L858R/vector	3.12±0.304	1.57±0.17	1.47±0.001
E746-A750 del/vector	1.78±0.147^∗	1.10±0.16	1.17±0.001
EGFR/vector	1.09±0.124^∗	1.16±0.20	0.55±0.000^∗

Data shown as average ± standard deviation (𝑛=3 for each tumor pair). All other three cell lines were compared to L858R tumor, and statistically significant difference (*𝑃<0.05) is indicated by an asterisk.