Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System

Table 4

Results of preliminary trials.

Parameters	P1	P2	P3	P4	P5	P6	P7	P8	P9
Drug loading (%)	91.77±3.45	82.46±3.72	89.74±4.70	88.24±2.87	84.40±3.88	SPHC; was not; formed	74.53±2.42	70.93±2.08	SPHC; was not; formed
Bioadhesion time (h)	8	7	5	8	8		8	8
CPR* (%)	99.10	100.84	100.20	98.03	94.98		87.22	81.24
𝑡^†100% (h)	2	3	2	5	8		8	8

∗CPR: cumulative percentage drug release; ^†𝑡_100%: time required for 100% drug release.