Review Article
Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
Table 1
14-3-3 isoforms in neurodegeneration.
| 14-3-3 isoform | Isoform-specific histology | Interacting partner and disease involvement |
| | Tangles in AD LBHI in ALS GCI in MSA | LRRK2; PD NFL mRNA; ALS Tau, SPRK2, FOXO1; AD Ataxin-1; SCA1 ASK1; Epilepsy GFAP; MS |
| | Tangles in AD Lewy bodies in PD LBH in ALS GCI in MSA | LRRK2; PD NFL mRNA; ALS |
| | Tangles in AD Lewy bodies in PD GCI in MSA | LRRK2; PD Cdc25, SPRK2; AD Ataxin-1; SCA1 GFAP; MS |
| | Tangles in AD Lewy bodies in PD Amyloid plaque in CJD GCI in MSA | Tyrosine hydroxylase, LRRK2; PD NFL mRNA; ALS GSK3, tau; AD Ataxin-1; SCA1 Huntingtin; HD Bad, Bax; Ischemia GFAP; MS |
| | ā | Parkin, LRRK2; PD NFL mRNA; ALS Tau; AD |
| | Tangles in AD | SPRK2; AD |
| | Lewy bodies in PD GCI in MSA | Bad, Bax, LRRK2; PD NFL mRNA; ALS |
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