565218.fig.002a
(a)
565218.fig.002b
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565218.fig.002c
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565218.fig.002d
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565218.fig.002e
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Figure 2: Chronic stress induces physiological and behavioural changes in a subgroup of anhedonic mice, which are not evident in mice resilient to stress. (a) A loss of sucrose preference was used to define the susceptible group, which was measured after the termination of a 10-day stress paradigm. (b) Latency to immobility in the tail suspension test was significantly shorter in stressed drug-naive animals than in control and stressed imipramine-treated groups. (c) The duration of immobility in the tail suspension test was significantly longer in stressed drug-naive than in control and stressed imipramine-treated groups. (d) In comparison to control mice, the score of coat state was significantly decreased in stressed nontreated mice and, to lesser extent, in stressed imipramine-treated animals. (e) Body weight was significantly reduced in both stressed group; it was significantly higher in imipramine-treated than in nontreated stressed groups. Data are mean ± SEM; , , and ; TST: tail suspension test.