Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms
Figure 3
Hippocampal gene expression of deiodinases 2 and 3 in a chronic stress depression model. Illumina assay has pointed to (a) a nonsignificant decrease in DIO2 expression in susceptible versus resilient mice and (b) significant elevation of DIO2 expression in stressed imipramine-treated group in comparison with stressed drug-naive animals. RTPCR analysis showed a significant (c) decrease in DIO2 expression in susceptible versus resilient mice and (d) increase in DIO2 expression in stressed imipramine-treated group in comparison with stressed nontreated mice. As for DIO3 expression, Illumina assay has revealed no significant differences in its expression between (e) susceptible versus resilient mice and (f) stressed imipramine-treated stressed drug-naive groups. RTPCR analysis demonstrated a lack of significant differences with the former comparison (g), but (h) showed a significant increase in DIO3 expression in stressed imipramine-treated group in comparison with stressed nontreated mice .
