Research Article

Ropivacaine-Induced Contraction Is Attenuated by Both Endothelial Nitric Oxide and Voltage-Dependent Potassium Channels in Isolated Rat Aortae

Figure 2

(a) The effect of endothelial denudation and N ω-nitro-L-arginine methyl ester (L-NAME) on ropivacaine concentration-response curves in isolated aortae. Data are shown as the mean ± SD and expressed as a percentage of the maximal contraction induced by isotonic 60 mM KCl (100% =  g [ ], 100% =  g [ ], and 100% =  g [ ] for untreated endothelium-intact aortae, untreated endothelium-denuded aortae, and endothelium-intact aortae treated with  M L-NAME, resp.). N indicates the number of rats from which descending thoracic aortic rings were derived. and versus endothelium-intact aortae. versus  M ropivacaine and versus  M in endothelium-intact aortae. (b) The effect of N ω-propyl-L-arginine hydrochloride and 1400W dihydrochloride on ropivacaine concentration-response curves in endothelium-intact aortae. Data are shown as the mean ± SD and expressed as a percentage of the maximal contraction induced by isotonic 60 mM KCl (100% =  g [ ], 100% =  g [ ], and 100% =  g [ ] for untreated endothelium-intact aortae, endothelium-intact aortae treated with  M N ω-propyl-L-arginine hydrochloride, and endothelium-intact aortae treated with  M 1400W dihydrochloride, resp.). N indicates the number of rats from which descending thoracic aortic rings were derived.
565271.fig.002a
(a)
565271.fig.002b
(b)