Ropivacaine-Induced Contraction Is Attenuated by Both Endothelial Nitric Oxide and Voltage-Dependent Potassium Channels in Isolated Rat Aortae

Figure 6

The effect of wortmannin (1×10⁻⁷ M) on ropivacaine concentration-response curves in endothelium-intact aortae. Data are shown as the mean ± SD and expressed as a percentage of the maximal contraction induced by isotonic 60 mM KCl (100% = 2.61±0.14 g [𝑛=5] and 100% = 2.46±0.20 g [𝑛=5] for untreated endothelium-intact aortae and endothelium-intact aortae treated with 1×10⁻⁷ M wortmannin, resp.). N indicates the number of rats from which descending thoracic aortic rings were derived.