Sensitivity of Rabbit Ventricular Action Potential and Ca²⁺ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients

Figure 3

Verification of ion conductance sensitivity predictions. Steady-state AP and Ca²⁺ transients (recorded 9-10 s) in each of the three non-SR compartments in response to 1 Hz stimulus. The predicted changes in APD₆₀ and Ca²⁺ peaks (see Insets also) are consistent with the generated by Nimrod/E and PLS outputs with respect to 10% increases in transporters’ conductance. Control conductance values (black solid line) and 10% increases in 𝐾_NCX (black dashed line), 𝑃_CaL (black dash-dot line), 𝐺_Kr (gray dash-dot line), 𝐺_to (gray solid line), 𝐾_NaK(gray dotted line), and 𝐺_ClBk (black dotted line).

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