Sensitivity of Rabbit Ventricular Action Potential and Ca²⁺ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients

Figure 5

Verification of transporter distribution sensitivity predictions. Steady-state model outputs (recorded 9-10 s) in response to 1 Hz periodic pulse. The predicted alterations in APD₆₀ and Ca²⁺ peaks (see Insets also) are consistent with the generated by Nimrod/E and PLS results with respect to 5% increases in transporters’ fraction in the junctional cleft. Default 𝑗-currents’ fractions in junctional cleft (black solid line) and 5% increases in 𝐹𝑥_CaL(jct) (black dashed line), 𝐹𝑥_Cl(Ca)(jct) (grey dotted line), 𝐹𝑥_NCX(jct) (black dash-dot line).

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