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BioMed Research International
Volume 2013 (2013), Article ID 569206, 13 pages
http://dx.doi.org/10.1155/2013/569206
Research Article

Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells

Defence Institute of Physiology and Allied Science, Lucknow Road, Timarpur, Delhi 110 054, India

Received 18 April 2013; Revised 11 July 2013; Accepted 11 July 2013

Academic Editor: Dobromir Dobrev

Copyright © 2013 Mrinalini Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Ward, Mountain Medicine: A Clinical Study of Cold and High Altitude, Crosby Lockwood staples, London, UK, 1975.
  2. M. Moehrle, B. Dennenmoser, and C. Garbe, “Continuous long-term monitoring of UV radiation in professional mountain guides reveals extremely high exposure,” International Journal of Cancer, vol. 103, no. 6, pp. 775–778, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. L. G. Pugh, “Tolerance to extreme cold at altitude in a Nepalese Pilgrim,” Journal of Applied Physiology, vol. 18, pp. 1234–1238, 1963. View at Scopus
  4. B. Shukitt-Hale, L. E. Banderet, and H. R. Lieberman, “Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia,” International Journal of Aviation Psychology, vol. 8, no. 4, pp. 319–334, 1998. View at Scopus
  5. A. R. Frisancho, “Functional adaptation to high altitude hypoxia,” Science, vol. 187, no. 4174, pp. 313–319, 1975. View at Scopus
  6. A. J. Peacock, “Medical problems of high altitude,” Journal of the Royal College of Physicians of Edinburgh, vol. 38, no. 2, pp. 126–128, 2008. View at Scopus
  7. I. Singh, P. K. Khanna, M. C. Srivastava, M. Lal, S. B. Roy, and C. S. Subramanyam, “Acute mountain sickness,” The New England Journal of Medicine, vol. 280, no. 4, pp. 175–184, 1969. View at Scopus
  8. “The Lake Louise Consensus on the definition and quantification of altitude illness,” in Hypoxia and Mountain Medicine: Proceedings of the 7th International Hypoxia Symposium Held at Lake Louise, Canada, February 1991, J. R. Sutton, G. Coates, and H. Houston, Eds., vol. 84 of Advances in the Biosciences, pp. 327–330, Pergamon, Oxford, UK, 1992.
  9. P. J. Barnes and M. Karin, “Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases,” The New England Journal of Medicine, vol. 336, no. 15, pp. 1066–1071, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Karin, “The beginning of the end: IκB kinase (IKK) and NF-κB activation,” Journal of Biological Chemistry, vol. 274, no. 39, pp. 27339–27342, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. N. K. Bhattarai, “Folk herbal medicines of Dolakha district, Nepal,” Fitoterapia, vol. 64, no. 5, pp. 387–395, 1993. View at Scopus
  12. K. Koyama, T. Imaizumi, M. Akiba et al., “Antinociceptive components of Ganoderma lucidum,” Planta Medica, vol. 63, no. 3, pp. 224–227, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. X. J. Gong, H. Ji, S. G. Lu, et al., “Effects of polysaccharides from cultured Cordyceps sinensis on murine immunologic function,” Zhongguo Yaoke Daxue Xuebao, vol. 31, pp. 53–55, 2000.
  14. Y. Yamaguchi, S. Kagota, K. Nakamura, K. Shinozuka, and M. Kunitomo, “Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis,” Phytotherapy Research, vol. 14, no. 8, pp. 647–649, 2000.
  15. Y. Z. Guo, “Medicinal chemistry, pharmacology and clinical applications of fermented mycelia of Cordyceps sinensis and JinShuBao capsule,” Journal of Modern Diagnostics and Therapeutics, vol. 1, pp. 60–65, 1986.
  16. J. S. Zhu and J. M. Rippe, “CordyMax enhances aerobic capability, endurance performance, and exercise metabolism in healthy, mid-age to elderly sedentary humans,” The FASEB Journal, vol. 18, no. 4, p. A931, 2004.
  17. T. Mizuno, “Medicinal effects and utilization of Cordyceps (Fr.) Link (Ascomycetes) and Isaria Fr. (Mitosporic fungi) Chinese caterpillar fungi, ‘Tochukaso’,” International Journal of Medicinal Mushrooms, vol. 1, no. 3, pp. 251–262, 1999.
  18. Z. D. Bao, Z. G. Wu, and F. Zheng, “Amelioration of aminoglycoside nephrotoxicity by Cordyceps sinensis in old patients,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 14, no. 5, pp. 259–271, 1994. View at Scopus
  19. D. G. Chen, “Effects of JinShuiBao capsule on the quality of life of patients with heart failure,” Journal of Administration of Traditional Chinese Medicine, vol. 5, pp. 40–43, 1995.
  20. D. B. Ji, J. Ye, and C. L. Li, “Antiaging effect of Cordyceps sinensis extract,” Phytotherapy Research, vol. 23, no. 1, pp. 116–122, 2009.
  21. D. K. Park, W. S. Choi, P.-J. Park et al., “Immunoglobulin and cytokine production from mesenteric lymph node lymphocytes is regulated by extracts of Cordyceps sinensis in C57Bl/6N mice,” Journal of Medicinal Food, vol. 11, no. 4, pp. 784–788, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. V. L. Singleton and J. A. Rossi, “Calorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents,” American Journal of Enology and Viticulture, vol. 16, pp. 144–158, 1965.
  23. J. Zhishen, T. Mengcheng, and W. Jianming, “The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals,” Food Chemistry, vol. 64, no. 4, pp. 555–559, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. I. F. F. Benzie and J. J. Strain, “The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay,” Analytical Biochemistry, vol. 239, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Burits and F. Bucar, “Antioxidant activity of Nigella sativa essential oil,” Phytotherapy Research, vol. 14, pp. 323–328, 2000.
  26. R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, and C. Rice-Evans, “Antioxidant activity applying an improved ABTS radical cation decolorization assay,” Free Radical Biology and Medicine, vol. 26, no. 9-10, pp. 1231–1237, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. O. H. Lowry, N. J. Rosebrough, A. L. Faro, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Scopus
  28. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Scopus
  29. R. L. Levine, D. Garland, C. N. Oliver et al., “Determination of carbonyl content in oxidatively modified proteins,” Methods in Enzymology, vol. 186, pp. 464–478, 1990. View at Publisher · View at Google Scholar · View at Scopus
  30. P. J. Hissin and R. Hilf, “A fluorometric method for determination of oxidized and reduced glutathione in tissues,” Analytical Biochemistry, vol. 74, no. 1, pp. 214–226, 1976. View at Scopus
  31. L. Costantino, A. Albasini, G. Rastelli, and S. Benvenuti, “Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase,” Planta Medica, vol. 58, no. 4, pp. 342–344, 1992. View at Scopus
  32. M. Y. Hui, B.-S. Wang, S. C. Huang, and P.-D. Duh, “Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage,” Journal of Agricultural and Food Chemistry, vol. 54, no. 8, pp. 3132–3138, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. C.-H. Dong and Y.-J. Yao, “In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis,” Food Science and Technology, vol. 41, no. 4, pp. 669–677, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. S. P. Li, P. Li, T. T. X. Dong, and K. W. K. Tsim, “Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia,” Phytomedicine, vol. 8, no. 3, pp. 207–212, 2001. View at Scopus
  35. P. A. Bauerle and T. Henkel, “Function and activation of NK-κB in the immune system,” Annual Review of Immunology, vol. 12, pp. 141–179, 1994.
  36. A. Y. Shih, P. Li, and T. H. Murphy, “A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo,” Journal of Neuroscience, vol. 25, no. 44, pp. 10321–10335, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Y. Chan and M. Kwong, “Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein,” Biochimica et Biophysica Acta, vol. 1517, no. 1, pp. 19–26, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Ishii, K. Itoh, S. Takahashi et al., “Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages,” Journal of Biological Chemistry, vol. 275, no. 21, pp. 16023–16029, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. L. E. Otterbein, M. P. Soares, K. Yamashita, and F. H. Bach, “Heme oxygenase-1: unleashing the protective properties of heme,” Trends in Immunology, vol. 24, no. 8, pp. 449–455, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Asghar, L. George, and M. F. Lokhandwala, “Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats,” American Journal of Physiology—Renal Physiology, vol. 293, no. 3, pp. F914–F919, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Hollander, R. Fiebig, M. Gore et al., “Superoxide dismutase gene expression in skeletal muscle: fiber-specific adaptation to endurance training,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 277, no. 3, pp. R856–R862, 1999. View at Scopus
  42. S. K. Powers and M. J. Jackson, “Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production,” Physiological Reviews, vol. 88, no. 4, pp. 1243–1276, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. C.-S. Zhao, W.-T. Yin, J.-Y. Wang et al., “CordyMax Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats,” Journal of Alternative and Complementary Medicine, vol. 8, no. 3, pp. 309–314, 2002. View at Scopus