Table 1: Protective effects of aqueous extract of Cordyceps sinensis on antioxidant status of cells exposed to hypoxia.

TreatmentGPx (U/L)SOD (U/mL)GR (U/L)GSH (mM)

Control400.7 ± 38.824.4 ± 1.7442.3 ± 2.239.01 ± 0.32
Hypoxia328.0 ± 22.2*48.4 ± 3.46*14.9 ± 0.82*3.34 ± 0.26*
Control + extract400.9 ± 18.926.6 ± 2.0243.8 ± 2.84 8.83 ± 0.33
Hypoxia + extract386.9 ± 20.432.7 ± 2.46*44.7 ± 2.627.86 ± 0.38

A549 cells were exposed to hypoxia (0.5% O2) for 48 h in the absence or presence of aqueous extract of Cordyceps sinensis (250 μg/mL). A significant decrease in GSH, GPx, and GR levels observed after hypoxia was restored in Cordyceps sinensis treated cells. Further, an increase in SOD activity was observed in cells exposed to hypoxia and the effect was nearly neutralized by Cordyceps sinensis treatment. Results are means ± SE of three individual experiments. * .