A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery

Table 1

Mass constituents comprising the MLMDT for both DTZ and THP formulations.

	DTZ MLMDT	THP MLMDT
Pectin barrier layer (PBL)	150 mg	150 mg
HPMC middle barrier layer 1 (HBL1)	150 mg^1	100 mg
HPMC outer barrier layer 2 (HBL2)	250 mg^1	200 mg
Lactose disk	160 mg	160 mg
Polymer disk (EC/HEC)	160 mg	160 mg
Total weight of tablet	870 mg	770 mg

1The DTZ MLMDT includes an additional 100 mg of sodium bicarbonate in the HPMC layers.