Table 1: Mass constituents comprising the MLMDT for both DTZ and THP formulations.

DTZ MLMDTTHP MLMDT

Pectin barrier layer (PBL)150 mg150 mg
HPMC middle barrier layer 1 (HBL1)150 mg1100 mg
HPMC outer barrier layer 2 (HBL2)250 mg1200 mg
Lactose disk160 mg160 mg
Polymer disk (EC/HEC)160 mg160 mg

Total weight of tablet870 mg770 mg

The DTZ MLMDT includes an additional 100 mg of sodium bicarbonate in the HPMC layers.