Table 2: Experimental formulation investigations showing (a) polymers, granulating, and bulking agents employed for THP formulations and (b) polymers, granulating, and bulking agents employed for DTZ formulations.
(a)

FormulationHEC (mg)EC (mg)HPMC (mg)Granulating agentBulking agent
SureleaseSureteric

170
270
370
470
550
635
770
823
970
103535
111456

(b)

FormulationHEC (mg)EC (mg)SureleaseSodium bicarbonate
QuantityLocation
Polymer disk (mg)HBL11HBL22

1284
132163
142163 100
152163 50
162163 150
172163 200
182163 300
192163 100
206321 100
214242

HBL1: HPMC middle barrier layer.
2HBL2: HPMC outer barrier layer.
Surelease: ethylcellulose.
Sureteric: polyvinyl acetate phthalate.