A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery

Table 2

Experimental formulation investigations showing (a) polymers, granulating, and bulking agents employed for THP formulations and (b) polymers, granulating, and bulking agents employed for DTZ formulations.

(a)  

Formulation	HEC (mg)	EC (mg)	HPMC (mg)	Granulating agent		Bulking agent
				Surelease	Sureteric
1	—	—	70	—	—	—
2	70	—	—	✓	✓	—
3	—	70	—	—	✓	—
4	—	70	—	✓	—	—
5	—	50	—	✓	—	✓
6	—	35	—	✓	—	✓
7	70	—	—	✓	—	—
8	—	23	—	✓	—	✓
9	—	—	70	✓	—	—
10	35	35	—	✓	—	—
11	14	56	—	✓	—	—

(b)  

Formulation	HEC (mg)	EC (mg)	Surelease	Sodium bicarbonate
				Quantity	Location
					Polymer disk (mg)	HBL1^1	HBL2^2
12	—	84	✓	—	—	—	—
13	21	63	✓	—	—	—	—
14	21	63	✓	100	—	✓	✓
15	21	63	✓	50	✓	—	—
16	21	63	✓	150	✓	✓	✓
17	21	63	✓	200	—	✓	✓
18	21	63	✓	300	✓	✓	✓
19	21	63	✓	100	✓	—	—
20	63	21	✓	100	—	✓	✓
21	42	42	✓	—	—	—	—

1HBL1: HPMC middle barrier layer.
²HBL2: HPMC outer barrier layer.
Surelease: ethylcellulose.
Sureteric: polyvinyl acetate phthalate.