A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery

Table 4

Friability, thickness, and mass uniformity for the DTZ and THP-loaded formulations (𝑁=10).

Formulation	Friability (%)	Thickness (mm)	Uniformity of mass1 (%)
THP MLMDT	0.3	4.82±0.03	99.6±0.4
THP lactose disk	0.9	1.78±0.02	99.4±0.6
THP polymer disk	0.5	2.08±0.02	99.6±0.4
DTZ MLMDT	0.3	5.18±0.03	99.7±0.3
DTZ lactose disk	0.8	1.78±0.02	99.9±0.1
DTZ polymer disk	0.4	2.14±0.04	99.5±0.5

1Expressed as a percentage of the theoretical weight.