A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery

Table 5

ANN results showing (a) data training diagnostics, (b) the best network run, (c) the ANN model fit parameters and, (d) combination of polymers to produce the optimum 𝑘₃.

(a)  

All runs	Training; minimum	Training standard; deviation
Average of minimum MSEs	0.016	0.0059
Average of final MSEs	0.016	0.0059

(b)  

Best network	Training
Run number	2
Epoch number	1000
Minimum MSE	0.0098
Final MSE	0.098

(c)  

Performance	𝑘3
MSE	4.51𝐸−06
NMSE	0.056
MAE	0.0015
Min abs error	0.00011
Max abs error	0.0053
Correlation coefficient 𝑅^2	0.98

(d)  

Sodium bicarbonate
Drug	Polymer	Polymer	Ratio	Quantity	HBL11	HBL22
THP	HEC	EC	1 : 3	—	—	—
DTZ	HEC	EC	1 : 1	100	✓	✓

1HBL1: HPMC middle barrier layer.
²HBL2: HPMC outer barrier layer.