Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants

Figure 2

Comparison of HFA227 formulations in terms of drug deposited on each stage of Next Generation Impactor, maintaining constant concentration of ethanol (data represent mean ± SD, 𝑛=3). MOC: microorifice collector. *𝑃<0.05 (ANOVA/Tukey’s) 5.45% w/w Pluronic L81 versus 0 and 1.22% w/w Pluronic L81, **𝑃<0.05 (ANOVA/Tukey’s) comparing all formulations, ^$𝑃<0.05 (ANOVA/Tukey’s) 1% w/w Pluronic L81 versus 0 and 5% w/w Pluronic L81, and ^#𝑃<0.05 (ANOVA/Tukey’s) 0% w/w Pluronic L81 versus 1.22 and 5% w/w Pluronic L81.