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BioMed Research International
Volume 2013 (2013), Article ID 574310, 7 pages
Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants
1School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
2Division of Pharmaceutics, College of Pharmacy, University of Texas at Austin, Austin, TX 78712-1113, USA
Received 26 March 2013; Accepted 2 July 2013
Academic Editor: Christine Dufès
Copyright © 2013 Imran Y. Saleem and Hugh D. C. Smyth. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. M. Courrier, N. Butz, and T. F. Vandamme, “Pulmonary drug delivery systems: recent developments and prospects,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 19, no. 4-5, pp. 425–498, 2002.
- C. A. Dunbar, “Atomization mechanisms of the pressurized metered dose inhaler,” Particulate Science and Technology, vol. 15, no. 3-4, pp. 253–271, 1997.
- K. J. McDonald and G. P. Martin, “Transition to CFC-free metered dose inhalers—into the new millennium,” International Journal of Pharmaceutics, vol. 201, no. 1, pp. 89–107, 2000.
- T. J. Noakes, “CFC’s their replacement and the ozone layer,” Journal of Aerosol Medicine, vol. 8, supplement 1, pp. S3–S7, 1995.
- C. Vervaet and P. R. Byron, “Drug-surfactant-propellant interactions in HFA-formulations,” International Journal of Pharmaceutics, vol. 186, no. 1, pp. 13–30, 1999.
- D. J. Alexander, “Safety of propellants,” Journal of Aerosol Medicine, vol. 8, no. 1, pp. S29–S34, 1995.
- F. E. Blondino and P. R. Byron, “Surfactant dissolution and water solubilization in chlorine-free liquified gas propellants,” Drug Development and Industrial Pharmacy, vol. 24, no. 10, pp. 935–945, 1998.
- H. D. C. Smyth, “The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers,” Advanced Drug Delivery Reviews, vol. 55, no. 7, pp. 807–828, 2003.
- C. L. Leach, P. J. Davidson, and R. J. Boudreau, “Improved airway targeting with the CFC-free HFA-beclomethasone metered- dose inhaler compared with CFC-beclomethasone,” European Respiratory Journal, vol. 12, no. 6, pp. 1346–1353, 1998.
- J. N. Pritchard, “The influence of lung deposition on clinical response,” Journal of Aerosol Medicine, vol. 14, no. 1, pp. S19–S26, 2001.
- H. D. C. Smyth and A. J. Hickey, “Multimodal particle size distributions emitted from HFA-134a solution pressurized metered-dose inhalers,” AAPS PharmSciTech, vol. 4, no. 3, p. E38, 2003.
- H. Smyth, G. Brace, T. Barbour, J. Gallion, J. Grove, and A. J. Hickey, “Spray pattern analysis for metered dose inhalers: effect of actuator design,” Pharmaceutical Research, vol. 23, no. 7, pp. 1591–1596, 2006.
- H. Smyth, A. J. Hickey, G. Brace, T. Barbour, J. Gallion, and J. Grove, “Spray pattern analysis for metered dose inhalers I: orifice size, particle size, and droplet motion correlations,” Drug Development and Industrial Pharmacy, vol. 32, no. 9, pp. 1033–1041, 2006.
- M. R. Feddah, K. F. Brown, E. M. Gipps, and N. M. Davies, “In-vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates,” Journal of Pharmacy & Pharmaceutical Sciences, vol. 3, no. 3, pp. 318–324, 2000.
- D. A. Lewis, D. Ganderton, B. J. Meakin, and G. Brambilla, “Theory and practice with soultion systems,” Respiratory Drug Delivery IX, vol. 1, pp. 109–116, 2004.
- Y. Gao, L. B. Li, and G. Zhai, “Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin,” Colloids and Surfaces B, vol. 64, no. 2, pp. 194–199, 2008.
- L. Bromberg, “Polymeric micelles in oral chemotherapy,” Journal of Controlled Release, vol. 128, no. 2, pp. 99–112, 2008.
- A. V. Kabanov, E. V. Batrakova, and V. Y. Alakhov, “Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery,” Journal of Controlled Release, vol. 82, no. 2-3, pp. 189–212, 2002.
- U. Chokshi, P. Selvam, L. Porcar, and S. R. P. da Rocha, “Reverse aqueous emulsions and microemulsions in HFA227 propellant stabilized by non-ionic ethoxylated amphiphiles,” International Journal of Pharmaceutics, vol. 369, no. 1-2, pp. 176–184, 2009.
- P. A. Dickinson, P. C. Seville, H. McHale, N. C. Perkins, and G. Taylor, “An investigation of the solubility of various compounds in the hydrofluoroalkane propellants and possible model liquid propellants,” Journal of Aerosol Medicine, vol. 13, no. 3, pp. 179–186, 2000.
- D. Traini, P. M. Young, P. Rogueda, and R. Price, “Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers,” International Journal of Pharmaceutics, vol. 320, no. 1-2, pp. 58–63, 2006.
- K. B. Ridder, C. J. Davies-Cutting, and I. W. Kellaway, “Surfactant solubility and aggregate orientation in hydrofluoroalkanes,” International Journal of Pharmaceutics, vol. 295, no. 1-2, pp. 57–65, 2005.
- R. N. Dalby and P. R. Byron, “Comparison of output particle size distributions from pressurized aerosols formulated as solutions or suspensions,” Pharmaceutical Research, vol. 5, no. 1, pp. 36–39, 1988.
- S. W. Stein, “Estimating the number of droplets and drug particles emitted from MDIs,” AAPS PharmSciTech, vol. 9, no. 1, pp. 112–115, 2008.
- S. W. Stein, “Aiming for a moving target: challenges with impactor measurements of MDI aerosols,” International Journal of Pharmaceutics, vol. 355, no. 1-2, pp. 53–61, 2008.
- S. W. Stein and P. B. Myrdal, “A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributions,” Journal of Pharmaceutical Sciences, vol. 93, no. 8, pp. 2158–2175, 2004.
- W. S. Stephen, “Size distribution measurements of metered dose inhalers using Andersen Mark II cascade impactors,” International Journal of Pharmaceutics, vol. 186, no. 1, pp. 43–52, 1999.
- B. J. Gabrio, S. W. Stein, and D. J. Velasquez, “A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers,” International Journal of Pharmaceutics, vol. 186, no. 1, pp. 3–12, 1999.
- S. W. Stein and P. B. Myrdal, “The relative influence of atomization and evaporation on metered dose inhaler drug delivery efficiency,” Aerosol Science and Technology, vol. 40, no. 5, pp. 335–347, 2006.
- A. H. de Boer, D. Gjaltema, P. Hagedoorn, and H. W. Frijlink, “Characterization of inhalation aerosols: a critical evaluation of cascade impactor analysis and laser diffraction technique,” International Journal of Pharmaceutics, vol. 249, no. 1-2, pp. 219–231, 2002.
- V. Naini, S. Chaudhry, J. Berry, S. Sharpe, J. Hart, and J. Sequeira, “Entry port selection for detecting particle size differences in metered dose inhaler formulations using cascade impaction,” Drug Development and Industrial Pharmacy, vol. 30, no. 1, pp. 75–82, 2004.