Table 4: Comparison of HFA 227 formulations with different concentrations of ethanol (data represent mean ± SD, ).

Ethanol concentration (% w/w)/(vapor pressure, psi)
5 (59.8 psi)10 (54.6 psi)13 (52.8 psi)15 (50.2 psi)

ED (μg)195.08 ± 23.25194.26 ± 14.19193.31 ± 12.44209.52 ± 11.02
FPF (%)54.31 ± 5.6545.39 ± 2.9035.02 ± 2.26**29.27 ± 0.77*
FPD (μg)105.07 ± 2.31±87.91 ± 1.73±67.52 ± 0.38±61.28 ± 1.79±
MMAD (μm)5.13 ± 0.235.05 ± 0.155.55 ± 0.185.79 ± 0.05*
GSD 1.74 ± 0.122.07 ± 0.011.73 ± 0.031.78 ± 0.01
VMD (μm)5.32 ± 0.548.03 ± 0.369.72 ± 0.5612.0 ± 0.44*

ED: emitted dose, MMAD: mass median aerodynamic diameter, FPF: fine particle fraction, FPD: fine particle dose, and GSD: geometric standard deviation. * (ANOVA/Tukey’s) 15% w/w EtOH versus 10 and 5% w/w EtOH, ** (ANOVA/Tukey’s) 13% w/w EtOH versus 10 and 5% w/w EtOH, and ± comparing all formulations (ANOVA/Tukey’s).