Table 3: CTLA-4 +49 A/G and −318 C/T genotype and allele distribution in tumor tissue of NSCLC patients in comparison with the control group.

CTLA-4 genotypes and allelesNSCLC patients
Healthy controls
OR (CI 95%) value
NumberFrequencyNumberFrequency

+49 AA190.27490.470.41 (0.21–0.78) 0.02
+49 AG250.35330.321.16 (0.62–2.21) 0.74
+49 GG270.38220.212.23 (1.17–4.48) 0.015

  

+49 A allele630.441310.630.47 (0.30–0.72)0.028
+49 G allele790.56770.372.13 (1.38–3.29)0.028
−318 CC240.33360.340.96 (0.91–1.82)0.15
−318 CT190.27370.360.66 (0.34–1.28)0.97
−318 TT280.40310.301.53 (0.81–2.89)0.41


−318 C allele670.471090.600.81 (0.53–1.24)0.32
−318 T allele750.53990.401.23 (1.80–1.89)0.32