Table 4: CTLA-4 +49 A/G and −318 C/T genotype and allele distribution in blood samples of NSCLC patients in comparison with the control group.

CTLA-4 genotypes and allelesNSCLC patients Healthy controls OR (CI 95%) value
NumberFrequencyNumberFrequency

+49 AA560.80490.474.19 (2.11–8.33)0.58
+49 AG130.18330.320.48 (0.23–1.02)0.23
+49 GG20.02220.210.11 (0.02–0.48)0.03


+49 A allele630.881310.634.32 (2.42–7.72)0.47
+49 G allele790.12770.370.23 (0.13–0.41)0.47
−318 CC590.83360.349.29 (0.42–9.48) 0.76
−318 CT100.14370.360.30 (0.14–2.65) 0.57
−318 TT20.03310.300.10 (0.02–0.30) 0.02


−318 C allele1280.901090.608.30 (0.5–15.36)0.23
−318 T allele140.10990.400.12 (0.65–2.22) 0.23