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BioMed Research International
Volume 2013 (2013), Article ID 581631, 9 pages
http://dx.doi.org/10.1155/2013/581631
Review Article

Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update

1Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
2Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Received 3 September 2012; Revised 17 December 2012; Accepted 7 January 2013

Academic Editor: Gerly A. C. Brito

Copyright © 2013 Yuan Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently advanced, while it is still challenged with high morbidity and poor prognosis. Infliximab, a monoclonal antibody of tumor necrosis factor (TNF), has emerged as an efficient treatment with many clinical benefits such as quick disease activity reduction and IBD patient life quality improvement. However, the biological effects of infliximab on IBD need to be elucidated. This paper reviewed the clinical use and recently advanced biological action of infliximab on IBD. By forming the stable complex with the soluble or the membrane form of TNF in fluid environment or on cell surface of immune cell, fibroblast, endothelium, and epithelium, infliximab quenches TNF activity and performs the important biological actions which lead to amelioration and remission of immune responses. The mechanisms of infliximab treatment for IBD were intensively discussed. The recent advances on two topics including predictors and side effects of infliximab treatment were also reviewed.