Review Article
Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update
Table 1
Mechanisms of infliximab treatment on IBD.
| Parameter | Effects | Ref. |
| Inflammatory cytokines, mediators | Downregulation | [18–21] | Activated lymphocytes | Apoptosis | [22–24] | Th1 | Downregulation | [25–28] | Treg, regulatory macrophage | Induction | [29–31] | Intestinal epithelial cells and barrier | Protection | [32, 33] | ICAM1, VCAM1 | Downregulation | [34] | Endothelial function | Protection | [35] | Mucosal angiogenesis | Inhibition | [36] | MMPs/TIMPs balance | Modulation | [37, 38] | Mucosa healing | Enhancing | [39] | NF-κB signals | Inhibition | [40] | MAPKs signaling | Promotion | [41]
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