Advances in the Applications of Polyhydroxyalkanoate Nanoparticles for Novel Drug Delivery System
Figure 4
Microscopic study showing the cellular internalization of the P(3HV-co-4HB)-b-mPEG NPs: (a) CLSM images of the DU145 prostate cancer cells treated with free rhodamine-123 for 12 h; (b) cells treated with rhodamine-loaded NPs for 12 h (scale bar 10 μm); (c) TEM images showing the uptake of NPs in DU145 prostate cancer cells incubated for 6 h (scale bar = 100 nm); (d) cells incubated for 12 h (scale bar = 200 nm). Arrows in the figure represent intracellular localization of NPs. Reprinted with permission from Shah et al. [15], Copyright (2012), Elsevier.
