Gene Entropy-Fractal Dimension Informatics with Application to Mouse-Human Translational Medicine

<table>The protein coding CDS 2D map of the studied mouse-human pairs. The <svg height="12.175" id="M22" style="vertical-align:-3.56265pt" version="1.1" viewbox="0 0 9.9624996 12.175" width="9.9624996" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,7.675)"><path d="M556 393q0 -39 -36 -106q-42 -78 -185 -279q-47 -66 -81 -108t-117 -135l-112 -26l-8 22q150 90 251 219q-6 136 -39 340q-8 53 -21 53q-6 0 -27 -19.5t-38 -42.5l-16 26q80 111 127 111q23 0 35 -28t20 -90q18 -137 27 -263h2q142 200 142 279q0 24 -14 48q-4 7 5 26
q13 28 43 28q18 0 30 -15.5t12 -39.5z" id="x1D466"></path></g>
</svg>-axis represents di-nucleotide entropy in bits per symbol, and <svg height="7.9499998" id="M23" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 9.625 7.9499998" width="9.625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,7.675)"><path d="M536 404q0 -17 -13.5 -31.5t-26.5 -14.5q-8 0 -15 10q-11 14 -25 14q-22 0 -67 -50q-47 -52 -68 -82l37 -102q31 -88 55 -88t78 59l16 -23q-32 -48 -68.5 -78t-65.5 -30q-19 0 -37.5 20t-29.5 53l-41 116q-72 -106 -114.5 -147.5t-79.5 -41.5q-21 0 -34.5 14t-13.5 37
q0 16 13.5 31.5t28.5 15.5q12 0 17 -11q5 -10 25 -10q22 0 57.5 36t89.5 111l-40 108q-22 58 -36 58q-21 0 -67 -57l-19 20q81 107 125 107q17 0 30 -22t39 -88l22 -55q68 92 108.5 128.5t74.5 36.5q20 0 32.5 -14t12.5 -30z" id="x1D465"></path></g>
</svg>-axis presents the fractal dimension. 16S rRNA (diamond), ID1 (square), PLCZ1 (cross), ESR1 (plus), and Myc (bar), have lower fractal dimension for human. LMNA (triangle), HAR1 (star), and RNF4 (circle) have higher fractal dimension for human.</table>

BioMed Research International

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Figure 2

Figure 2: Gene Entropy-Fractal Dimension Informatics with Application to Mouse-Human Translational Medicine 