Polymorphisms in the Human Cytochrome P450 and Arylamine N-Acetyltransferase: Susceptibility to Head and Neck Cancers

Table 2

Summary of studies on CYPs450 and NATs genes status in HNC.

Gene	Population	𝑁; (case/control)	SNP (allele or genotype)	OR	95% CI	𝑃 value	References
CYP1A1	Japanese	100/100	*2A/*2A	3.6	1.4–9.5	<0.05	[69]
	Indian	—	*1A/*2A	1.76	1.19–2.60	—	[66]
			*2A/*2A	2.83	1.43–5.61	—
	Indian	458/729	m2/m2	3.2	1.10–10.28	0.05	[64]
	Korean	72/221	m2/m2	3.8	1.9–7.7	0.023	[63]
	Brazilian	153/145	*1A/*2A	—	—	0.003	[67]
	Japanese	142/142	m2/m2	2.3	1.1–4.7	<0.05	[54]
	Indian	408/220	MspI^a+	6.43	3.69–11.21	<0.05	[65]
			MspI^c+	10.24	5.95–17.60	<0.05
	Brazilian	103/102	MspI^+	2.4	1.13–5.10	—	[68]
	Indian	203/201	T3801C	4.89	3.15–7.32	<0.01	[89]
	Japanese	145/164	*2A/*2A	4.1	1.1–15	0.038	[55]
	Chinese	278/278	3798 CC	2.39	1.11–5.16	0.027	[71]
	Indian	205/245	m1/m1	8.12	3.27–21.30	0.000002	[79]
			w1/m1	1.96	1.14–3.38	0.0092
			m2/m2	6.31	2.24–18.69	0.000015
	Polish	289/316	*4/*4	1.70	0.99–2.88	0.049	[56]
	Caucasian (meta-analysis)	—		1.29	1.05–1.65	—	[70]
	22 studies (meta-analysis)	4168/4638	MspI^+	—	1.15–1.57	<0.001	[59]
			MspI^a	2.98	1.69–5.26	<0.001
CYP1B1	Indian	150/150	*2 (wt/mt)	2.36	1.27–4.38	0.04	[21]
			*2 (mt/mt)	3.34	1.20–9.36	0.03
			*2 (wt/mt)^a	2.37	1.62–4.85	<0.05
			*2 (wt/mt or mt/mt)^a	4.47	2.07–9.60
			*2 (wt/mt or mt/mt)^c	8.81	2.60–29.87	<0.05
			*3 (wt/mt or mt/mt)^c	2.74	1.12–6.70	<0.05
	German	195/177	*3^a, f	4.53	2.62–7.98	<0.001	[26]
CYP2D6	Indian	350/350	*4 (mt/mt)	2.32	1.14–4.34	<0.001	[135]
			*10 (wt/mt)	2.06	1.48–2.87	<0.001
			*10 (mt/mt)	1.85	1.19–2.89	<0.001
	Polish	289/316	*4/*4 (1934GG)	2.36	1.03–5.39	0.045	[56]
CYP2E1	Brazilian	153/145	*5B	190.6	24.50–1483	<0.0001	[67]
	Chinese	320/320	*5B	2.46	1.78–4.04	<0.01	[160]
	Indian	—	*5B	3.44	1.45–8.14	—	[147]
			*6	1.76	1.45–2.41	—
	German	312/299	−71 G>T	0.49	0.25–0.98	0.04	[159]
	Chinese	755/755	rs9418990^d	2.95	1.68–5.17	0.0002	[170]
			rs8192780^d	2.99	1.72–5.21	0.0001
			rs1536826^d	2.94	1.69–5.13	0.0001
			rs3827688^d	1.88	1.13–3.13	0.0140
	CaucasianAfrican-American	113/226	c1/c1^e	—	—	0.033	[146]
		58/173
	24 studies (meta-analysis)	12,562/—	*5B				[164]
			c2 allele	1.11	1.00–1.22	0.04
			c2/c2	1.57	1.14–2.15	0.006
	17 studies (meta-analysis)	1,663/2,603	c1/c2	0.64	0.50–0.81	<0.001	[158]
	24 studies (meta-analysis)	12,562 (all)	c2/c2	1.57	1.14–2.15	0.006	[206]
	21 studies (meta-analysis)	4,951/6,071	*5B	1.96	1.33–2.90	<0.05	[93]
			*6	1.56	1.06–2.27	<0.05
	Asian (meta-analysis)	4,951/6,071	*5B	2.04	1.32–3.15	<0.05	[93]
			*6	2.04	1.27–3.29	<0.05
NAT1	Japanese	62/122	*10	3.72	1.56–8.90	<0.01	[199]
			*10^a	3.14	1.09–9.07	0.017
			*10^b	5.88	1.13–30.6	0.022
NAT2	Brazilian	231/212	*4/*4	1.95	1.05–3.60	0.035	[53]
	German	255/510	*4	2.18	1.13–4.22	0.018	[195]
	Greek	88/102	*4	2.20	1.23–3.95	0.0087	[197]
	American (USA)	203/416	*4	1.55	1.08–2.20	0.03	[198]
	Tunisian	64/160	*5B	1.82	2.68–12.26	0.04	[194]
	Tunisian	45/100	*6A	6.14	2.4–14	<0.05	[193]
	Polish	289/316	*4/*6A	3.24	1.1–9.75	0.045	[56]
			*5B/*5B	3.41	1.6–9.9	0.043
	Spanish	75/200	*6A	0.30	0.10–0.89	<0.042	[133]
			*5B	0.48	0.25–0.93	<0.039
		145/164	—	2	—	0.039	[55]

aSmokers; ^bnonsmokers; ^cchewers; ^dsmokers <46 years; ^esubjects smoked <24 pack-years; ^fcalculation for wt/wt genotype versus wt/mt and mt/mt genotypes.
—: undefined; +: the genotype/allele undefined.