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BioMed Research International
Volume 2013 (2013), Article ID 583513, 10 pages
http://dx.doi.org/10.1155/2013/583513
Research Article
Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System
1Department of Health Science, POLARIS Research Center, University of Milan-Bicocca, 48 Via Cadore, 20900 Monza, Italy
2Department of Environmental Science, POLARIS Research Center, University of Milan-Bicocca, 1 piazza della Scienza, Milan 20126, Italy
Received 23 July 2012; Revised 12 October 2012; Accepted 18 October 2012
Academic Editor: Abderrahim Nemmar
Copyright © 2013 Francesca Farina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- G. Polichetti, S. Cocco, A. Spinali, V. Trimarco, and A. Nunziata, “Effects of particulate matter (PM10, PM2.5 and PM1) on the cardiovascular system,” Toxicology, vol. 261, no. 1-2, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Salvi and S. T. Holgate, “Mechanisms of particulate matter toxicity,” Clinical and Experimental Allergy, vol. 29, no. 9, pp. 1187–1194, 1999. View at Publisher · View at Google Scholar · View at Scopus
- U. Heinrich, U. Mohr, R. Fuchst, and C. Brockmeyer, “Investigation of a potential co-tumorigenic effect of the dioxides of nitrogen and sulphur and of diesel engine exhaust on the respiratory tract of Syrian golden hamsters,” Research Report 29, Health Effects Institute, Cambridge, Mass, USA, 1989.
- P. Mantecca, F. Farina, E. Moschini et al., “Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles,” Toxicology Letters, vol. 198, no. 2, pp. 244–254, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Nemmar, H. Vanbilloen, M. F. Hoylaerts, P. H. M. Hoet, A. Verbruggen, and B. Nemery, “Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 9, pp. 1665–1668, 2001. View at Scopus
- W. G. Kreyling, M. Semmler, F. Erbe et al., “Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low,” Journal of Toxicology and Environmental Health Part A, vol. 65, no. 20, pp. 1513–1530, 2002. View at Publisher · View at Google Scholar · View at Scopus
- G. Oberdörster, Z. Sharp, V. Atudorei et al., “Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats,” Journal of Toxicology and Environmental Health Part A, vol. 65, no. 20, pp. 1531–1543, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. Nemmar, P. H. M. Hoet, B. Vanquickenborne et al., “Passage of inhaled particles into the blood circulation in humans,” Circulation, vol. 105, no. 4, pp. 411–414, 2002. View at Publisher · View at Google Scholar · View at Scopus
- N. L. Mills, N. Amin, S. D. Robinson et al., “Do inhaled carbon nanoparticles translocate directly into the circulation in humans?” American Journal of Respiratory and Critical Care Medicine, vol. 173, no. 4, pp. 426–431, 2006. View at Publisher · View at Google Scholar · View at Scopus
- F. Farina, G. Sancini, P. Mantecca, D. Gallinotti, M. Camatini, and P. Palestini, “The acute toxic effects of particulate matter in mouse lung are related to size and season of collection,” Toxicology Letters, vol. 202, no. 3, pp. 209–217, 2011. View at Publisher · View at Google Scholar · View at Scopus
- R. Vecchi, G. Marcazzan, G. Valli, M. Ceriani, and C. Antoniazzi, “The role of atmospheric dispersion in the seasonal variation of PM1 and PM2.5 concentration and composition in the urban area of Milan (Italy),” Atmospheric Environment, vol. 38, no. 27, pp. 4437–4446, 2004. View at Publisher · View at Google Scholar · View at Scopus
- M. Giugliano, G. Lonati, P. Butelli, L. Romele, R. Tardivo, and M. Grosso, “Fine particulate (PM2.5-PM1) at urban sites with different traffic exposure,” Atmospheric Environment, vol. 39, no. 13, pp. 2421–2431, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. Gualtieri, P. Mantecca, V. Corvaja et al., “Winter fine particulate matter from Milan induces morphological and functional alterations in human pulmonary epithelial cells (A549),” Toxicology Letters, vol. 188, no. 1, pp. 52–62, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. Mantecca, G. Sancini, E. Moschini et al., “Lung toxicity induced by intratracheal instillation of size-fractionated tire particles,” Toxicology Letters, vol. 189, no. 3, pp. 206–214, 2009. View at Publisher · View at Google Scholar · View at Scopus
- N. Sabbagh-Kupelwieser, H. Horvath, and W. W. Szymanski, “Urban aerosol studies of PM1 size fraction with reference to ambient conditions and visibility,” Aerosol and Air Quality Research, vol. 10, no. 5, pp. 425–432, 2010. View at Publisher · View at Google Scholar · View at Scopus
- G. Lonati and M. Giugliano, “Size distribution of atmospheric particulate matter at traffic exposed sites in the urban area of Milan (Italy),” Atmospheric Environment, vol. 40, supplement 2, pp. 264–274, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. G. Perrone, M. Gualtieri, L. Ferrero et al., “Seasonal variations in chemical composition and in vitro biological effects of fine PM from Milan,” Chemosphere, vol. 78, no. 11, pp. 1368–1377, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Ferrero, M. G. Perrone, S. Petraccone et al., “Vertically-resolved particle size distribution within and above the mixing layer over the Milan metropolitan area,” Atmospheric Chemistry and Physics, vol. 10, no. 8, pp. 3915–3932, 2010. View at Scopus
- M. G. Perrone, B. R. Larse, L. Ferrero et al., “Sources of high PM2.5 concentrations in Milan, Northern italy: molecular marker data and CMB modelling,” Science of the Total Environment, vol. 414, pp. 343–355, 2012. View at Publisher · View at Google Scholar
- M. Naota, A. Shimada, T. Morita, K. Inoue, and H. Takano, “Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: possible association of diffusion and caveolae-mediated pinocytosis,” Toxicologic Pathology, vol. 37, no. 4, pp. 456–462, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Chen, M. Tan, A. Nemmar et al., “Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats: effect of lipopolysaccharide,” Toxicology, vol. 222, no. 3, pp. 195–201, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. S. Happo, R. O. Salonen, A. I. Hlinen et al., “Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities,” Inhalation Toxicology, vol. 22, no. 5, pp. 402–416, 2010. View at Publisher · View at Google Scholar · View at Scopus
- V. Saunders, P. Breysse, J. Clark, A. Sproles, M. Davila, and M. Wills-Karp, “Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent,” Environmental Health Perspectives, vol. 118, no. 5, pp. 640–646, 2010. View at Publisher · View at Google Scholar · View at Scopus
- H. R. Paur, F. R. Cassee, J. Teeguarden et al., “In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung-A dialog between aerosol science and biology,” Journal of Aerosol Science, vol. 42, no. 10, pp. 668–692, 2011. View at Publisher · View at Google Scholar · View at Scopus
- R. Daffara, L. Botto, E. Beretta et al., “Endothelial cells as early sensors of pulmonary interstitial edema,” Journal of Applied Physiology, vol. 97, no. 4, pp. 1575–1583, 2004. View at Publisher · View at Google Scholar · View at Scopus
- R. F. Henderson, “Use of bronchoalveolar lavage to detect respiratory tract toxicity of inhaled material,” Experimental and Toxicologic Pathology, vol. 57, no. 1, pp. 155–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. T. Kleinman, C. Sioutas, M. C. Chang, A. J. F. Boere, and F. R. Cassee, “Ambient fine and coarse particle suppression of alveolar macrophage functions,” Toxicology Letters, vol. 137, no. 3, pp. 151–158, 2003. View at Publisher · View at Google Scholar · View at Scopus
- M. Lundborg, S. E. Dahlén, U. Johard et al., “Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages,” Environmental Research, vol. 100, no. 2, pp. 197–204, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. L. Mauderly, M. B. Snipes, and E. B. Barr, “Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats,” Report 68, Health Effects Institute, Cambridge, Mass, USA, 1994.
- S. Salvi, A. Blomberg, B. Rudell et al., “Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers,” American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 3, pp. 702–709, 1999. View at Scopus
- D. M. Walters, P. N. Breysse, and M. Wills-Karp, “Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in mice,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 8, pp. 1438–1443, 2001. View at Scopus
- A. K. Cho, C. Sioutas, A. H. Miguel et al., “Redox activity of airborne particulate matter at different sites in the Los Angeles Basin,” Environmental Research, vol. 99, no. 1, pp. 40–47, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. E. Gerlofs-Nijland, A. Campbell, M. R. Miller, D. E. Newby, and F. R. Cassee, “Toxicity of inhaled traffic related particulate matter,” Journal of Physics: Conference Series, vol. 151, Article ID 012049, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Becker, L. A. Dailey, J. M. Soukup, S. C. Grambow, R. B. Devlin, and Y. C. T. Huang, “Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress,” Environmental Health Perspectives, vol. 113, no. 8, pp. 1032–1038, 2005. View at Publisher · View at Google Scholar · View at Scopus
- L. E. Fredenburgh, M. A. Perrella, and S. A. Mitsialis, “The role of heme oxygenase-1 in pulmonary disease,” American Journal of Respiratory Cell and Molecular Biology, vol. 36, no. 2, pp. 158–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. W. Ryter and R. M. Tyrrell, “The heme synthesis and degradation pathways: role in oxidant sensitivityHeme oxygenase has both pro- and antioxidant properties,” Free Radical Biology and Medicine, vol. 28, no. 2, pp. 289–309, 2000. View at Publisher · View at Google Scholar · View at Scopus
- T. A. Reiter and B. Demple, “Carbon monoxide mediates protection against nitric oxide toxicity in HeLa cells,” Free Radical Biology and Medicine, vol. 39, no. 8, pp. 1075–1088, 2005. View at Publisher · View at Google Scholar · View at Scopus
- L. Risom, M. Dybdahl, J. Bornholdt et al., “Oxidative DNA damage and defense gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation,” Carcinogenesis, vol. 24, no. 11, pp. 1847–1852, 2003. View at Publisher · View at Google Scholar · View at Scopus
- B. Y. Chin, M. A. Trush, A. M. K. Choi, and T. H. Risby, “Transcriptional regulation of the HO-1 gene in cultured macrophages exposed to model airborne particulate matter,” American Journal of Physiology, vol. 284, no. 3, pp. L473–L480, 2003. View at Scopus
- P. H. Danielsen, P. Møller, K. A. Jensen et al., “Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines,” Chemical Research in Toxicology, vol. 24, no. 2, pp. 168–184, 2011. View at Publisher · View at Google Scholar · View at Scopus
- G. Li Volti, V. Sorrenti, P. Murabito et al., “Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury,” Transplantation Proceedings, vol. 39, no. 10, pp. 2986–2991, 2007. View at Publisher · View at Google Scholar · View at Scopus
- H. Greim and R. Snyder, Toxicology and Risk Assessment: A Comprehensive Introduction, John Wiley & Sons, 2008.
- Q. Cao, S. Zhang, C. Dong, and W. Song, “Pulmonary responses to fine particles: differences between the spontaneously hypertensive rats and wistar kyoto rats,” Toxicology Letters, vol. 171, no. 3, pp. 126–137, 2007. View at Publisher · View at Google Scholar · View at Scopus
- A. Elder and G. Oberdörster, “Translocation and effects of ultrafine particles outside of the lung,” Clinics in Occupational and Environmental Medicine, vol. 5, no. 4, pp. 785–796, 2005. View at Publisher · View at Google Scholar · View at Scopus
- C. J. Obot, M. T. Morandi, T. P. Beebe, R. F. Hamilton, and A. Holian, “Surface components of airborne particulate matter induce macrophage apoptosis through scavenger receptors,” Toxicology and Applied Pharmacology, vol. 184, no. 2, pp. 98–106, 2002. View at Publisher · View at Google Scholar · View at Scopus
- T. Stoeger, S. Takenaka, B. Frankenberger et al., “Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-Free oxidative potency assay and Metabolic activation of organic compounds,” Environmental Health Perspectives, vol. 117, no. 1, pp. 54–60, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Marschall, M. A. Rothschild, and M. Bohnert, “Expression of heat-shock protein 70 (Hsp70) in the respiratory tract and lungs of fire victims,” International Journal of Legal Medicine, vol. 120, no. 6, pp. 355–359, 2006. View at Publisher · View at Google Scholar · View at Scopus
- D. Kültz, “Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function,” Journal of Experimental Biology, vol. 206, no. 18, pp. 3119–3124, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Hertel, A. Viehmann, S. Moebus et al., “Influence of short-term exposure to ultrafine and fine particles on systemic inflammation,” European Journal of Epidemiology, vol. 25, no. 8, pp. 581–592, 2010. View at Publisher · View at Google Scholar · View at Scopus
- G. Oberdörster and M. J. Utell, “Ultrafine particles in the urban air: to the respiratory tract—and beyond?” Environmental Health Perspectives, vol. 110, no. 8, pp. A440–A441, 2002. View at Scopus
- R. Para, Evaluation of toxicological effects of intra tracheal instilled CeO2 nanoparticles on the heart of male sprague-dawley rats [Ph.D. thesis], 2011.
- J. Zhao, Y. Xie, X. Qian, R. Jiang, and W. Song, “Acute effects of fine particles on cardiovascular system: differences between the spontaneously hypertensive rats and wistar kyoto rats,” Toxicology Letters, vol. 193, no. 1, pp. 50–60, 2010. View at Publisher · View at Google Scholar · View at Scopus
- E. Cozzi, C. J. Wingard, W. E. Cascio et al., “Effect of ambient particulate matter exposure on hemostasis,” Translational Research, vol. 149, no. 6, pp. 324–332, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. Massberg, K. Brand, S. Grüner et al., “A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation,” Journal of Experimental Medicine, vol. 196, no. 7, pp. 887–896, 2002. View at Publisher · View at Google Scholar · View at Scopus
- I. Weinberger, J. Fuchs, E. Davidson, and Z. Rotenberg, “Circulating aggregated platelets, number of platelets per aggregate, and platelet size during acute myocardial infarction,” American Journal of Cardiology, vol. 70, no. 11, pp. 981–983, 1992. View at Publisher · View at Google Scholar · View at Scopus
- G. Chironi, C. Dosquet, M. Del-Pino et al., “Relationship of circulating biomarkers of inflammation and hemostasis with preclinical atherosclerotic burden in nonsmoking hypercholesterolemic men,” American Journal of Hypertension, vol. 19, no. 10, pp. 1025–1031, 2006. View at Publisher · View at Google Scholar · View at Scopus