About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 584105, 8 pages
http://dx.doi.org/10.1155/2013/584105
Research Article

Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions

1UMR 7245 MCAM MNHN CNRS, Muséum National d’Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, France
2UMR 5554 ISEM CNRS, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier, France
3UMR 5236 Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), 34095 Montpellier, France

Received 26 April 2013; Revised 24 July 2013; Accepted 26 July 2013

Academic Editor: Heather Simpson

Copyright © 2013 Adélaïde Nieguitsila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Filariae are a leading cause of infections which are responsible for serious dermatological, ocular, and vascular lesions. Infective third stage larvae (L3) are transmitted through the bite of a haematophagous vector. Litomosoides sigmodontis is a well-established model of filariasis in the mouse, with the vector being the mite Ornithonyssus bacoti. The aim of the study was to analyse the filarial infection in mites to determine the consequences of filarial infection in the blood-feeding and the reproduction of mites as well as in the regulation of vector-induced inflammation in the mouse skin. Firstly, L3 are unevenly distributed throughout the host population and the majority of the population harbours a moderate infection (1 to 6 L3). Filarial infection does not significantly affect the probing delay for blood feeding. The number of released protonymphs is lower in infected mites but is not correlated with the L3 burden. Finally, induced excreted proteins from infected mites but not from uninfected mites stimulate TNF-α and the neutrophil-chemoattractant KC production by antigen-presenting cells (APCs). Altogether, these results describe the modification of the mite behavior under filarial infection and suggest that the immunomodulatory capacity of the mite may be modified by the presence of the parasite, hindering its defensive ability towards the vertebrate host.