|
Infectious agent | Strain | Cell type | Effects | Experimental techniques | Ref. |
|
Trypanosome cruzi | Tulahuen | Primary culture of rat neonatal cardiomyocytes | ↓ dye coupling | Junctional conductance and dye transfer of Lucifer yellow | [50] |
| | | ↓ Cx43 expression at junctional membrane regions | Immunofluorescence | |
|
Trypanosome cruzi | Tulahuen | Primary culture of rat neonatal astrocytes | ↓ dye coupling | Dye transfer of Lucifer yellow | [49] |
| | | = Cx43 expression at 72 hours p.i. | Western blot (Cx43) | |
| | | Cx43 phosphorylation state at 72 hours p.i. | Western blot (Cx43) and electrophoretic mobility | |
| | | ↓ Cx43 immunoreactivity | Immunostaining (Cx43) | |
| | Primary culture of rat leptomeningeal cells | ↓ dye coupling |
Dye transfer of Lucifer yellow | |
| | | = Cx43 expression at 72 hours p.i. | Western blot (Cx43) | |
| | | = Cx43 phosphorylation state at 72 hours p.i. | Western blot (Cx43) and electrophoretic mobility | |
| | | ↓ Cx43 and Cx26 immunoreactivity | Immunostaining (Cx43, Cx26) | |
| Brazil | Murine infection | ↓ Cx43 expression at 4 weeks p.i. | Immunofluorescence | |
|
Trypanosome cruzi |
Y | Primary culture of mouse neonatal cardiomyocytes | ↑ Cx43 expression and phosphorylation at 1 hour p.i. |
Western blot (Cx43) | [50] |
| | | ↓ Cx43 expression at 48 and 72 hours p.i. | Immunostaining (Cx43) | |
| | Murine infection | ↓ Cx43 in atria and ventricle at 11 days p.i. | Confocal microscopy (Cx43) |
| | | ↓ Cx43 plaque distribution |
|
Trypanosome cruzi |
Colombian |
C57BL/6 mice | ↓ Cx43 expression at 28 and 32 days p.i. |
Immunohistochemistry (Cx43) | [54] |
| | B6.129-Tnfraf1a (p55/60)-deficient mice | = Cx43 expression at 28 and 32 days p.i. | | |
|
Trypanosome cruzi |
Colombian |
C3H/He (H-2K) mice | ↓ Cx43 expression at 150 and 180 days p.i. |
Immunohistochemistry (Cx43) | [51] |
| | Met-RANTES-treated C3H/He (H-2K) mice | = Cx43 expression at 150 and 180 days p.i. | | |
|
Trypanosome cruzi |
Y | Primary culture of mouse neonatal cardiomyocytes | ↓ Cx43 expression at 48 hours p.i. |
Immunohistochemistry (Cx43) | [53] |
| | Left ventricle fragments from the heart of CCC patients | ↓ Cx43 plaque number | | |
| | | ↓ Cx43 plaque size | | |
|
Trypanosome cruzi |
Colombian | Primary culture of mouse neonatal cardiomyocytes | ↓ Cx43 gene |
Microarray assay | [61] |
| | | ↑ Cx37 gene | | |
| | | = Cx40 and Cx45 gene | | |
|
Toxoplasma gondii |
ME49 | Primary culture of rat neonatal astrocytes | ↓ dye coupling | Dye transfer of Lucifer yellow | [49] |
| | | = Cx43 expression at 72 hours p.i. | Western blot (Cx43) | |
| | | = Cx43 phosphorylation state at 72 hours p.i. | Western blot (Cx43) and electrophoretic mobility | |
| | | ↓ Cx43 immunoreactivity | Immunostaining (Cx43) | |
| | Primary culture of rat leptomeningeal cells | ↓ dye coupling | Dye transfer of Lucifer yellow | |
| | | = Cx43 expression at 72 hours p.i. | Western blot (Cx43) | |
| | | = Cx43 phosphorylation state at 72 hours p.i. | Western blot (Cx43) and electrophoretic mobility | |
| | | ↓ Cx43 and Cx26 immunoreactivity | Immunostaining (Cx43, Cx26) | |
| | Murine infection | ↓ Cx43 expression at 12 weeks p.i. | Immunofluorescence | |
|