Table 1: List of miRSNPs evaluated in cancer susceptibility studies.

SNP categoryCancer typeSNPGeneOR (95% CI)Reference

miRNA sequence

Any cancerrs11614913miR-196a21.18 (1.03–1.34)[24]

Bladder cancerrs2910164miR-146-a0.80 (0.71–0.90)[12]

rs895819miR-27a0.88 (0.78–0.99)[33]
rs2910164miR-146-a1.31 (1.05–1.65)[17]
rs11614913miR-196a21.23 (1.02–1.48)[23]
Breast cancerrs6505162miR-4230.50 (0.27–0.92)[26]
rs3746444miR-4991.25 (1.02–1.51)[23]
rs3746444miR-4991.10 (1.01–1.20)[28]
rs4919510miR-6081.62 (1.23–2.15)[32]

Cervical cancerrs3746444miR-4991.98 (1.36–2.89)[29]

rs213210miR-219-13.22 (1.70–6.10)[30]
Colorectal carcinomars6505162miR-4232.12 (1.34–3.34)[27]
rs4919510miR-6082.72 (1.38–5.33)[30]

Esophageal cancerrs213210miR-219-11.75 (1.10–2.80)[25]
rs6505162miR-4230.64 (0.51–0.80)[25]

Gastric cancerrs895819miR-27a1.48 (1.06–2.05)[37]

Nasopharyngeal carcinomars2910164miR-146-a0.49 (0.35–0.69)[13]

Non-small cell lung cancerrs11614913miR-196a21.76 (1.34–2.32)[19]

Papillary thyroid carcinoma rs2910164miR-146-a1.62 (1.3–2.0)[11]

Renal carcinomars895819miR-27a0.71 (0.56–0.90)[36]

Binding site

Bladder cancer1010A/GHOXB5 1.48 (1.07–2.06)[60]

rs61764370KRAS 1.47 (1.05–2.06)[39]
Breast cancerrs7963551RAD52 0.84 (0.75–0.95)[50]
rs1044129RYR3 1.26 (1.03–1.54)[59]
rs334248TGFBR1 2.2 (1.29–4.07)[47]

Colorectal carcinomars17281995CD86 2.93 (1.29–6.67)[58]
rs1051690INSR 2.06 (1.19–3.56)[58]

Non-small cell lung cancerrs61764370KRAS 1.36 (1.07–1.73)[38]

Ovarian cancerrs61764370KRAS 1.67 (1.09–2.57)[43]
rs4245739MDM4 5.5 (1.5–20.5)[61]

Small-cell lung cancerrs3134615MYCL1 2.08 (1.39–3.21)[49]
rs16917496SET8 0.45 (0.22–0.94)[54]

Squamous cell carcinoma of the head and neckrs1049253CASP3 1.29 (1.07–1.56)[56]

Biogenesis pathway

Breast cancerrs11786030AGO2 2.62 (1.41–4.88)[66]
rs2292779AGO2 2.94 (1.52–5.69)[66]

Head and neck cancerrs1057035DICER 0.65 (0.46–0.92)[69]

Non-small cell lung cancerrs11077XPO5 1.77 (1.07–2.91)[68]

rs2740348GEMIN4 0.64 (0.42–0.99)[67]
Prostate cancerrs7813GEMIN4 2.53 (1.07–6.28)[67]
rs3744741GEMIN4 0.69 (0.50–0.96)[67]

rs2740348GEMIN4 0.67 (0.47–0.96)[64]
Renal carcinomars7813GEMIN4 0.68 (0.47–0.98)[64]
rs910925GEMIN4 1.74 (1.15–1.62)[65]
rs3744741GEMIN4 0.39 (0.19–0.77)[65]