Research Article
Acute Toxicity and the Effect of Andrographolide on Porphyromonas gingivalis-Induced Hyperlipidemia in Rats
Table 1
Effect of andrographolide on blood lipids in hyperlipidemic rats.
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(TC) Total cholesterol; (4,25) = 137.7, < 0.001, (LDL-C) low-density lipoprotein; (4,25) = 33.49, < 0.001, (HDL-C) High-density lipoprotein; (4,25) = 72.6, < 0.001, (TG) triglycerides; (4,25) = 20.5, < 0.001. Group (1) vehicle; Group (2) vehicle and P. gingivalis; Group (3) simvastatin (100 mg/kg); Group (4) andrographolide 20 mg/kg; Group (5) andrographolide 10 mg/kg. Statistical analysis of the data was carried out using a one-way analysis of variance (ANOVA) and Dennett’s post hoc test for average comparison on SPSS 18.0. Mean values SEM ( = 6) were used. Significance was defined as < 0.05 compared to G2. Values without an asterisk do not have significant difference compared to G2. |