Table 1: Effect of andrographolide on blood lipids in hyperlipidemic rats.

TC (mmol/L)LDL-C (mmol/L)HDL-C (mmol/L)TG (mmol/L)

Group 11.55 ± 0.02*1.48 ± 0.04*0.085 ± 0.002*0.483 ± 0.04
Group 21.8 ± 0.001.63 ± 0.010.147 ± 0.0040.55 ± 0.02
Group 31.35 ± 0.02*1.33 ± 0.04*0.088 ± 0.003*0.28 ± 0.03*
Group 41.78 ± 0.01*1.38 ± 0.01*0.093 ± 0.033*0.25 ± 0.02*
Group 51.33 ± 0.01*1.24 ± 0.01*0.085 ± 0.002*0.35 ± 0.02*

(TC) Total cholesterol; (4,25) = 137.7, < 0.001, (LDL-C) low-density lipoprotein; (4,25) = 33.49, < 0.001, (HDL-C) High-density lipoprotein; (4,25) = 72.6, < 0.001, (TG) triglycerides; (4,25) = 20.5, < 0.001.
Group (1) vehicle; Group (2) vehicle and P. gingivalis; Group (3) simvastatin (100 mg/kg); Group (4) andrographolide 20 mg/kg; Group (5) andrographolide 10 mg/kg. Statistical analysis of the data was carried out using a one-way analysis of variance (ANOVA) and Dennett’s post hoc test for average comparison on SPSS 18.0. Mean values SEM ( = 6) were used. Significance was defined as < 0.05 compared to G2. Values without an asterisk do not have significant difference compared to G2.