Acute Toxicity and the Effect of Andrographolide on Porphyromonas gingivalis-Induced Hyperlipidemia in Rats

Table 1

Effect of andrographolide on blood lipids in hyperlipidemic rats.

	TC (mmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)	TG (mmol/L)
Group 1	1.55 ± 0.02*	1.48 ± 0.04*	0.085 ± 0.002*	0.483 ± 0.04
Group 2	1.8 ± 0.00	1.63 ± 0.01	0.147 ± 0.004	0.55 ± 0.02
Group 3	1.35 ± 0.02*	1.33 ± 0.04*	0.088 ± 0.003*	0.28 ± 0.03*
Group 4	1.78 ± 0.01*	1.38 ± 0.01*	0.093 ± 0.033*	0.25 ± 0.02*
Group 5	1.33 ± 0.01*	1.24 ± 0.01*	0.085 ± 0.002*	0.35 ± 0.02*

(TC) Total cholesterol; 𝐹 (4,25) = 137.7, 𝑃 < 0.001, (LDL-C) low-density lipoprotein; 𝐹 (4,25) = 33.49, 𝑃 < 0.001, (HDL-C) High-density lipoprotein; 𝐹 (4,25) = 72.6, 𝑃 < 0.001, (TG) triglycerides; 𝐹 (4,25) = 20.5, 𝑃 < 0.001.
Group (1) vehicle; Group (2) vehicle and P. gingivalis; Group (3) simvastatin (100 mg/kg); Group (4) andrographolide 20 mg/kg; Group (5) andrographolide 10 mg/kg. Statistical analysis of the data was carried out using a one-way analysis of variance (ANOVA) and Dennett’s post hoc test for average comparison on SPSS 18.0. Mean values ± SEM (𝑛 = 6) were used. Significance was defined as 𝑃 < 0.05 compared to G2. Values without an asterisk do not have significant difference compared to G2.