Research Article
Acute Toxicity and the Effect of Andrographolide on Porphyromonas gingivalis-Induced Hyperlipidemia in Rats
Table 3
Effect of andrographolide on liver biomarkers in hyperlipidemic rats.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Albumin (4,25) = 11.2, < 0.001, (TB) Total bilirubin; (4,25) = 4.2, < 0.05, (AP) Alkaline phosphatase; (4,25) = 27.4, < 0.001, (ALT) Alanine aminotransferase; (4,25) = 21.7, < 0.001, (AST) Aspartate aminotransferase; (4,25) = 9.9, < 0.001. Group (1) vehicle; Group (2) vehicle and P. gingivalis; Group (3) simvastatin (100 mg/kg); Group (4) andrographolide 20 mg/kg; Group (5) andrographolide 10 mg/kg. Statistical Analysis of the data was carried out using a one-way analysis of variance (ANOVA) and Dennett’s post hoc test for average comparison on SPSS 18.0. Mean values SEM ( = 6) were used. Significance was defined as * < 0.05 compared to G2. Values without an asterisk do not have significant difference compared to G2. |