Review Article
The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability
Table 2
Concentrations (in mol/L) of micronutrients that can increase genomic stability in traditional cell-culture media and FBS versus human serum.
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NA: not available. *MEM: minimum essential medium; DMEM: Dulbecco's modified eagle medium; L-15: Leibovitzs medium 15; M-199: medium-199; HAM F-10 and F-12: Ham's nutrient mixture F-10 and F-12; RPMI-1640: Roswell Park Memorial Institute medium; DMEM/HAM F-12: Dulbecco's modified eagle medium/Ham's nutrient mixture F-12. The vitamin and mineral concentrations described were obtained from the webpages of the key suppliers. **The values for the vitamin A, vitamin E, and selenium concentration in FBS were found in [144], and the iron concentration in FBS was determined analytically. ***The references citing the micronutrient concentrations in human serum are as follows: vitamins A [145], B7 [146], B9 [147], B12 [148], C, and E [149]; Mg [150]; Cu, Fe, Se, and Zn [151]. The concentration of the vitamins and minerals in the media were obtained from the manufacturers. |