A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder

Table 2

ENCODE annotations of regions for TNFSF4 rs2205960 and rs10489265.

SNP	Enhancer histone marks*	DNAse-I hypersensitivity*	Protein binding	Regulatory motifs
rs2205960	GM12878	GM12878, Th1, GM12864	BATF, BCL11A, MEF2A, NF-𝜅B
rs10489265	HSMM	AG10803, HFF-Myc		GR, Hdx, RXRA, STAT

∗ENCODE cell types that show enhancer histone or DNAse-I hypersensitivity regions that overlap SNPs.
GM12878: B-lymphocyte, lymphoblastoid; GM12864: B-lymphocyte, lymphoblastoid; HSMM: skeletal muscle myoblasts; AG10803: abdominal skin fibroblasts; HFF-Myc: foreskin fibroblast cells expressing canine cMyc.
Regulation annotations were identified using HaploReg.