Table 1: Summary of the relevant TH target genes in hepatocyte.

Physiological functionGene nameUpregulated by TH/TRDownregulated by TH/TRGenomic actionNongenomic actionReference

Homeostasis controlErα[61]
HIF-1α[58, 68]

Ion transporterKCNH2[71]

Cellular metabolismGLUT1[68]
PFKP[68]
MCT 4[68]
mGPDH[13, 94]
CPT-1[13, 94]
SREBP-1c[13, 94]
PPARα[95]
PPARδ[95]
PPARγ[95]
ACOX[95]
SCD[95]
ATGL[95]
Apo B[95]
AKR1B1[26]

Cellular death controlTRAIL[25]
Bcl-xL[25]

InflammationCOX-2[12]
STAT3[12]

Cell growth controlTGF-β[125]
CDK2[125]
PTTG1[24]

Cell metastasisPAI-1[133]
uPAR[133]
PRSS22[133]
Cathepsin H[140]
DKK4[27]
MAT1A[162]
Spondin 2[161]