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BioMed Research International
Volume 2013 (2013), Article ID 604635, 6 pages
http://dx.doi.org/10.1155/2013/604635
Research Article

Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice

1Department of Pharmacology, ABC Medical School, FMABC, Avenue Príncipe de Gales 821, 09060-650 Santo Andre, SP, Brazil
2Department of Medicine, ABC Medical School, FMABC, Avenue Príncipe de Gales 821, 09060-650 Santo Andre, SP, Brazil
3Federal University of São Paulo (UNIFESP), Rue Prof. Artur Riedel 270, 09972-270 Diadema, SP, Brazil
4Department of Neurology, ABC Medical School, FMABC, Avenue Príncipe de Gales 821, 09060-650 Santo Andre, SP, Brazil
5Department of Pharmacology, University of São Paulo (USP), Avenue Professor Lineu Prestes 152, 05508-900 São Paulo, SP, Brazil

Received 21 June 2012; Accepted 6 September 2012

Academic Editor: Fabio Ferreira Perazzo

Copyright © 2013 David Feder et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Several evidences show that muscles have an endocrine function. Glucocorticoid, estrogen, progesterone, and testosterone receptors have already been found in normal skeletal muscles, but not in dystrophic muscles. Methods. The gene expression of hormone receptors was compared between dystrophic and healthy muscles in mdx and C57BL6 mice strains. Results. The mdx mice showed a significant increase in the steroid receptors mRNA when compared to the C57BL6 mice: levels of androgen(s) receptors in the heart, estrogen receptors alpha in the EDL, and estrogen receptors beta in the quadriceps were increased. In addition, significant lowered levels of some other hormone receptors were found: corticosteroid receptors in the EDL and estrogen receptors alpha in the quadriceps. Conclusion. Dystrophic muscles bear significant differences in the expression of hormone receptors when compared to the C57BL6 mice strain. The importance of such differences is yet to be better understood.